Clinical Research Innovation and Education Center Tohoku University Hospital

Clinical Research, Innovation and Education Center, Tohoku University Hospital

Tohoku University Hospital Clinical Research Center, as well as to support the research and development of the medical system, we will bridge to practical use in a clinical setting the results of basic research.

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Shinji Kamakura

Bone Regenerative Therapy by Octacalcium Phosphate Collagen Composites (OCP/Col)

Development supervisor

Shinji Kamakura
Professor, Bone Regenerative Engineering Laboratory, Regenerative and Biomedical Engineering Division, Graduate School of Biomedical Engineering, Tohoku University

Currently, an implantation of autogenous bone is a gold standard for bone regeneration, whereas it has disadvantages such as limited availability and morbidity associated with harvesting bone from a second operative site.

Shinji Kamakura image

Professor Kamakura et al. have developed a new biomimetic bone regenerative material of OCP/Col, which is constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagen. And it has the characteristics as follows:
1) OCP/Col achieved sufficient bone regeneration without exogenous cell transplantation and cytokines.
2) OCP/Col-derived bone would be coordinated with physiological bone remodeling, and indicated similar structure as well as original bone.
3) OCP/Col which has no need of complicated operation and management system is easy directions for use and has prominent cost-benefit effect.
These effects have been reported at the scientific conferences and published in journals over the past decade.

With the spread of bone regenerative therapy by OCP/Col, it would be expected the reduction of autologous bone grafting and alleviation of pain for patients. Because this therapy utilizes the natural function of cells in the body, OCP/Col would be applicable for bone regeneration in emergency surgery, orthopedics, and bone defects due to craniotomy or thoracotomy.


Figure legends

  1. Figure 1: OCP/collagen composites (OCP/Col) is a sponge-like and soft material. It can be easily inserted in the shape of the bone defect.
  2. Figure 2: Bone regenerative process after OCP/Col implantation in rodent calvarial defects
    Radiographic changes are indicated in upper row. Although OCP/Col itself has little radiopacity and appears black, the OCP/Col-implanted site becomes fused and condensed with time. Histological changes are indicated in lower row. Many cells are invaded into the reticulum of OCP/Col sponge, and new bone (B) is formed. After implantation of eight weeks, newly formed bone matured (B) and OCP/Col has been resorbed with bone remodeling.
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